Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor |
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| Authors: | Ray-Chang Wu Martina Blumenthal Xinwei Li Axel H Schönthal |
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| Affiliation: | (1) Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, CA, USA;(2) Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;(3) K. Norris Jr. Comprehensive Cancer Center, University of Southern California, 2011 Zonal Ave, HMR-405, Los Angeles, CA 90089, USA |
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| Abstract: | Background The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous PTEN was able to suppress their ability to grow anchorage-independently, and thus reverted one of the typical characteristics of tumor cells. As these findings indicated that PTEN might be involved in the regulation of anchorage-dependent cell growth, we analyzed this aspect of PTEN function in non-tumor cells with an anchorage-dependent phenotype. |
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