Effects of multiple phorbol myristate acetate treatments on cyclic nucleotide levels in mouse epidermis. |
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Authors: | S J Garte S Belman |
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Institution: | Institute of Environmental Medicine New York University Medical Center New York, New York 10016 USA |
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Abstract: | The basal levels of 3′,5′ adenosine monophosphate and 3′,5′ guanosine monophosphate were measured in mouse epidermis after initiation with 7,12 dimethylbenzanthracene and 1,2,10 or 20 skin treatments with the tumor promoter phorbol myristate acetate. Slight but significant decreases in cAMP and dramatic (5–10 fold) increases in cGMP were found after multiple treatments with the promoter. The cyclic nucleotide levels found in isolated solid tumors closely paralleled these changes. |
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