Role of the Rep helicase gene in homologous recombination in Neisseria gonorrhoeae |
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| Authors: | Kline Kimberly A Seifert H Steven |
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| Affiliation: | Department of Microbiology and Immunology, Northwestern University Feinberg University School of Medicine, 303 East Chicago Ave., Chicago, IL 60611, USA. |
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| Abstract: | In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair. |
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