Thrombin induces rapid PAR1-mediated non-classical FGF1 release |
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Authors: | Duarte Maria Kolev Vihren Soldi Raffaella Kirov Alexander Graziani Irene Oliveira Silvia Marta Kacer Doreen Friesel Robert Maciag Thomas Prudovsky Igor |
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Institution: | Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA. |
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Abstract: | Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis. |
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Keywords: | Thrombin PAR1 FGF1 Non-classical release |
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