Primary Structure and Tissue Distribution of Guinea Pig Gastrin-Releasing Peptide |
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| Authors: | C. Shaw L. Thim J. M. Conlon |
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| Affiliation: | Clinical Research Group for Gastrointestinal Endocrinology of the Max-Planck-Gesellschaft, University of G?ttingen, F.R.G. |
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| Abstract: | The primary structure of gastrin-releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin-releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin-releasing peptide and its COOH-terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin-releasing peptide. Within the small intestine, highest concentrations of gastrin-releasing peptide-like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers. |
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| Keywords: | Gastrin-releasing peptide Neuromedin C Guinea pig gastrointestinal tract Edman degradation |
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