A new mechanism for membrane iron transport in Pseudomonas aeruginosa |
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Authors: | Schalk I J Abdallah M A Pattus F |
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Institution: | Département des Récepteurs et Protéines Membranaires UPR 9050 CNRS, ESBS, Bld Sébastien Brant, F-67400 Illkirch, Strasbourg, France. schalk@esbs.u-strasbg.fr |
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Abstract: | Various biochemical and biophysical studies have demonstrated the existence of a novel iron-uptake mechanism in Pseudomonas aeruginosa, different from that generally described for ferrichrome and ferric-enterobactin in Escherichia coli. This new iron-uptake mechanism involves all the proteins generally reported to be involved in the uptake of ferric-siderophore complexes in Gram-negative bacteria (i.e. the outer membrane receptor, periplasmic binding protein and ATP-binding-cassette transporter), but differs in the behaviour of the siderophore. One of the key features of this process is the binding of iron-free pyoverdin to the outer membrane receptor FpvA in conditions of iron deficiency. |
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