In silico screening for tumour-specific expressed sequences in human genome. |
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Authors: | A V Baranova A V Lobashev D V Ivanov L L Krukovskaya N K Yankovsky A P Kozlov |
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Institution: | Vavilov Institute of General Genetics, 3 Gubkina Str., Moscow 119991, Russia. baranova@vigg.ru |
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Abstract: | A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression. |
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