A mathematical model of the dynamics of granulocytopoiesis in mammals

A mathematical model has been developed for the dynamics of granulocytopoiesis in mammals subjected to chronic irradiation. The model involves a chalones mechanism of haemopoiesis regulation and comprises 12 nonlinear differential equations. The simulation results agree with the experimental data concerning the dynamics of granulocytopoiesis in rats affected by radiation within a wide range of dose rates.