Invited contribution: An objective approach to the development of short-term tests predictive of carcinogenicity |
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| Authors: | Herbert S Rosenkranz Fanny K Ennever Vira Chankong Julia Pet-Edwards Yacov Y Haimes |
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| Institution: | (1) Department of Environmental Health Sciences, Case Western Reserve University, 44106 Cleveland, Ohio;(2) Department of Systems Engineering, Case Western Reserve University, Cleveland, Ohio |
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| Abstract: | The Carcinogenicity Prediction and Battery Selection procedure was developed to address two problems: (1) the identification of highly predictive, yet cost-effective, batteries of short-term tests and (2) the objective prediction of the potential carcinogenicity of chemicals based upon the results of short-term tests even when a mixture of positive and negative results is obtained. In the present report the usefulness of the Carcinogenicity Prediction and Battery Selection procedure is demonstrated using benzoa]pyrene, benzoin and diethylstilbestrol as examples. In addition, its applicability in the analysis of all the possible outcomes of a battery is illustrated together with an analysis of the worth of additional testing.Abbreviations Ba]P
benzoa]pyrene
- CASE
Computer-Automated Structure Evaluation
- CPBS
Carcinogenicity Prediction and Battery Selection
- DEHP
diethylhexylphthalate
- DES
diethylstilbestrol
- NTA
nitrilotriacetate
- TCDD
2,3,7,8-tetrachlorodibenzo-p-dioxin |
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| Keywords: | computer-based methodologies genotoxic carcinogens predictive batteries short-term testing |
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