The effect of exposure to positive space charge on aversive responses to noxious stimuli in rats |
| |
| Authors: | C J Beardwood A Abrahams P M Jordi |
| |
| Affiliation: | 1. Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, 342037, India;2. National Centre for Cell Science (NCCS), Ganeshkhind, Pune, Maharashtra, 411007, India;3. Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, 492010, India;4. Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore, Madhya Pradesh, 453552, India;5. School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh, 175005, India |
| |
| Abstract: | Exposure of rats to positive atmospheric ions for four days or longer results in an increase in aversive response times (tail flick and hot-plate). While these effects are similar to those produced after opiate administration, they could not be inhibited by naloxone treatment. Prompt reversal of the positive ion analgesic effect, however was brought about by treatment with parachlorophenylalanine which lowers brain serotonin levels. The data suggest that the action of positive ions on the pain inhibitory system is dependent upon an intact serotonin pathway and that the effects on this system are mediated via central rather than peripheral neural mechanisms. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
