Protease inhibitor (Pi) locus,fertility and twinning |
| |
Authors: | D I Boomsma R R Frants R A Bank N G Martin |
| |
Institution: | (1) Department of Psychonomics, Free University, De Boelelaan 1111, NL-1081 HV Amsterdam, The Netherlands;(2) Institute of Human Genetics, Free University, Amsterdam, The Netherlands;(3) Department of Human Genetics, Leiden University, Leiden, The Netherlands;(4) Queensland Institute of Medical Research, Brisbane, Queensland, Australia |
| |
Abstract: | Summary In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|