Microfluidic tools toward industrial biotechnology |
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| Authors: | Aline F. Oliveira Amanda C. S. N. Pessoa Reinaldo G. Bastos Lucimara G. de la Torre |
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| Affiliation: | 1. Department of Bioprocesses and Materials Engineering, School of Chemical Engineering, University of Campinas, Campinas;2. Department of Agroindustrial Technology and Rural Socioeconomy, Center of Agricultural Sciences, Federal University of S?o Carlos, Araras |
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| Abstract: | Microfluidics is a technology that operates with small amounts of fluids and makes possible the investigation of cells, enzymes, and biomolecules and encapsulation of biocatalysts in a greater variety of conditions than permitted using conventional methods. This review discusses technological possibilities that can be applied in the field of industrial biotechnology, presenting the principal definitions and fundamental aspects of microfluidic parameters to better understand advanced approaches. Specifically, concentration gradient generators, droplet‐based microfluidics, and microbioreactors are explored as useful tools that can contribute to industrial biotechnology. These tools present potential applications, inclusive as commercial platforms to optimizing in bioprocesses development as screening cells, encapsulating biocatalysts, and determining critical kinetic parameters. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1372–1389, 2016 |
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| Keywords: | microfluidics concentration gradient generator droplet‐based microbioreactor industrial biotechnology |
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