The tissue distribution of fructose-2,6-p2 and fructose-6-P,2-kinase in rats and the effect of starvation diabetes and hypoglycemia on hepatic fructose-2,6-P2 and fructose-6-P,2-kinase |
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Authors: | M Kuwajima K Uyeda |
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Affiliation: | 1. Veterans Administration Medical Center, Dallas, Texas 75216 USA.;2. the University of Texas Health Science Center, Department of Biochemistry, Dallas, Texas 75235 USA. |
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Abstract: | The tissue distribution of fructose-2,6-P2 and fructose-6-P,2-kinase in rats was determined. The highest concentration of fructose-2,6-P2 was found in liver, followed by brain, heart muscle, kidney, testis and skeletal muscle in decreasing order. Similar results were obtained with fructose-6-P,2-kinase activities in these tissues. Starvation, streptozotocin-induced diabetes or hypoglycemia lowers the fructose-2,6-P2 levels and fructose-6-P,2-kinase activity in the liver. |
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