Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil |
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| Authors: | H K Mangold T Muramatsu B S Roughley N Weber |
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| Institution: | 1. Bundesanstalt für Fettforschung, Institut für Biochemie und Technologie, H.P. Kaufmann-Institut, Piusallee 68, D-4400 Münster, FRG;2. Tokyo Medical and Dental University, Department of General Education, Tokyo 272, Japan;3. Amersham International plc, Cardiff Laboratories, Forest Farm Whitchurch, Cardiff CF4 7YT, Wales UK |
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| Abstract: | 1-O-Alkyl-2,3-diacyl-sn-glycerols, the major constituents of ratfish (Chimaera monstrosa) liver oil, serve as starting material for the preparation of 1-O-alkyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholines, and 1-O-alkyl-2-O-methyl-sn-glycero-3-beta-D-glucopyranosides. Catalytic tritiation of the unsaturated alkyl moieties in these biologically active ether lipids affords the corresponding 3H-labeled substances. |
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