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3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation |
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| Authors: | Lin Ronghui Lu Yanhua Wetter Steven K Connolly Peter J Turchi Ignatius J Murray William V Emanuel Stuart L Gruninger Robert H Fuentes-Pesquera Angel R Adams Mary Pandey Niranjan Moreno-Mazza Sandra Middleton Steven A Jolliffe Linda K |
| Affiliation: | Johnson & Johnson Pharmaceutical Research & Development L.L.C., Drug Discovery, 1000 Route 202, Raritan, New Jersey 08869, USA. rlin@prdus.jnj.com |
| Abstract: | A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells. |
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