| 神经酸及其在预防和治疗脑病中的应用研究进展 |
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| 引用本文： | 李文保,孙昌俊,王飞飞,李岱龙,颜廷和. 神经酸及其在预防和治疗脑病中的应用研究进展[J]. 微生物学杂志, 2014, 38(8) |
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| 作者姓名： | 李文保 孙昌俊 王飞飞 李岱龙 颜廷和 |
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| 作者单位： | 济南圣鲁金药物技术开发有限公司, 山东 济南 250101；济宁银枫农业科技有限公司, 山东 济宁 273200,济南圣鲁金药物技术开发有限公司, 山东 济南 250102,济南圣鲁金药物技术开发有限公司, 山东 济南 250103,济宁银枫农业科技有限公司, 山东 济宁 273200,济宁银枫农业科技有限公司, 山东 济宁 273201 |
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| 摘 要： | 神经酸是大脑神经细胞和组织中的一种核心天然成分，具有特殊的生物学功能, 对人体健康尤其是脑健康起到至关重要的作用。综述神经酸的生物功能和作用机制、神经酸的制备（包括从元宝枫油中提取分离、化学合成及转基因生物合成）以及神经酸在预防和治疗脑病（包括多发性硬化症、肾上腺脑白质营养不良、Zellweger 综合征、阿尔茨海默病等）中的应用研究进展。
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| 关 键 词： | 神经酸；生物功能；作用机制；制备；元宝枫油；合成；脑病 |
Advances in Research on Nervonic Acid and Its Applications in Prevention and Treatment of Encephalopathy |
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| LI Wenbao,SUN Changjun,WANG Feifei,LI Dailong and YAN Tinghe. Advances in Research on Nervonic Acid and Its Applications in Prevention and Treatment of Encephalopathy[J]. Journal of Microbiology, 2014, 38(8) |
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| Authors: | LI Wenbao SUN Changjun WANG Feifei LI Dailong YAN Tinghe |
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| Affiliation: | Jinan Sanlugen Pharma Tech Ltd., Jinan 250101, China;Jining Yinfeng Agriculture Tech Ltd., Jining 273200, China,Jinan Sanlugen Pharma Tech Ltd., Jinan 250101, China,Jinan Sanlugen Pharma Tech Ltd., Jinan 250102, China,Jining Yinfeng Agriculture Tech Ltd., Jining 273200, China and Jining Yinfeng Agriculture Tech Ltd., Jining 273201, China |
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| Abstract: | Nervonic acid is one of core natural ingredients with special biological function in brain nerve cells and tissues, which plays a crucial role in human health, especially in brain health. The advances in research on the biological function and mechanism of action of nervonic acid, its preparation (including extraction and separation from acer truncatum oil, chemical synthesis and transgenic biosynthesis) and its applications in the prevention and treatment of encephalopathy (including multiple sclerosis, adrenoleukodystrophy, Zellweger syndrome, Alzhemier''s disease and so on) were reviewed. |
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| Keywords: | nervonic acid biological function mechanism of action preparation acer truncatum oil synthesis encephalopathy |
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