海洋天然活性产物Fascaplysin 的研究进展

Fascaplysin 是从海绵中发现的一种海洋天然活性产物, 具有抗肿瘤、抗细菌、抗真菌、抗病毒、抗疟疾、抑制胆碱酯酶等多种生物活性。近年来，Fascaplysin 被发现能选择性抑制抗肿瘤靶标——细胞周期蛋白依赖性激酶4, 因而备受关注。综述Fascaplysin 的抗肿瘤机制、全合成及结构改造的研究进展。

Advances in Research on Marine Bioactive Compound Fascaplysin

Fascaplysin, a marine active product discoverd from sponge, shows various bioactivities including antitumor, antimicrobial, antifungal, antiviral, antimalarial, cholinesterase inhibitory effects, etc. Recently, it has been found that Fascaplysin possesses a specific inhibitory effect on cyclin dependent kinase 4(CDK4) to be a promising antitumor target which can promote tumor cell proliferation. Therefore, Fascaplysin has drawn a wide academic attention. The advances in research on the antitumor mechanism, total synthesis and structural modification of Fascaplysin were reviewed.