| PARP-1 抑制剂靶向治疗上皮性卵巢癌的研究进展 |
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| 引用本文： | 陈小祥,刘琦. PARP-1 抑制剂靶向治疗上皮性卵巢癌的研究进展[J]. 微生物学杂志, 2014, 38(10) |
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| 作者姓名： | 陈小祥 刘琦 |
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| 作者单位： | 南京医科大学附属肿瘤医院江苏省肿瘤医院妇瘤科，江苏 南京 210009,南京军区南京总医院妇产科，江苏 南京 210002 |
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| 基金项目： | ：国家自然科学基金（No. 81472441）；江苏省自然科学基金（No.BK20131439）；江苏省六大人才高峰课题（No. 2013-WSN-062） |
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| 摘 要： | 简介聚二磷酸腺苷核糖聚合酶-1（PARP-1）及其功能和在DNA 损伤修复中的作用，综述PARP-1 抑制剂的作用机制、发展现状以及在上皮性卵巢癌治疗中的应用，并探讨PARP-1 抑制剂靶向治疗上皮性卵巢癌的临床试验失败原因，展望PARP-1 抑制剂的应用前景，提出需对PARP-1 抑制剂在用于治疗上皮性卵巢癌中的耐药机制和选择性展开深入研究。
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| 关 键 词： | 聚二磷酸腺苷核糖聚合酶-1；DNA 损伤修复；抑制剂；上皮性卵巢癌 |
Prospect in PARP-1 Inhibitors as Targeted Therapeutics for Epithelial Ovarian Cancer |
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| CHEN Xiaoxiang and LIU Qi. Prospect in PARP-1 Inhibitors as Targeted Therapeutics for Epithelial Ovarian Cancer[J]. Journal of Microbiology, 2014, 38(10) |
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| Authors: | CHEN Xiaoxiang and LIU Qi |
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| Affiliation: | Department of Gynecologic Oncology, Jiangsu Cancer Hospital, Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009,China; and Department of Gynecology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China |
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| Abstract: | Poly(ADP-ribose) polymerase-1(PARP-1), its function and effect in DNA damage repair were introduced. The mechanism of action, the development status and the application of PARP-1 inhibitors in the treatment of epithelial ovarian cancer were reviewed. The reasons for the failure of PARP-1 inhibitors as targeted therapeutics in clinical trials for the treatment of epithelial ovarian cancer were discussed. And the application prospect of PARP 1 inhibitors and the need for further investigation into the epithelial ovarian cancer resistance mechanisms and selectivity to PARP-1 inhibitor treatment were suggested for discussion. |
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| Keywords: | PARP-1 DNA damage repair inhibitor epithelial ovarian cancer |
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