Potential metabolites of a condensed 2,3-benzodiazepine derivative |
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| Authors: | Csuzdi Emese Migléczi Katalin Hazai István Berzsenyi Pál Pallagi István Horváth Gyula Lengyel György Sólyom Sándor |
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| Institution: | IVAX Drug Research Institute Ltd., H-1045 Budapest, Berlini u. 47-49, Hungary. |
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| Abstract: | Putative metabolites of an AMPA antagonist imidazo-2,3-benzodiazepine (2) were synthesized and compared to constituents formed from the parent compound by a rat liver perfusion method. As metabolic transformations, hydroxylation of the 2-methyl group and N-acetylation of the amino functionality in parent compound (2) were registered. The hydroxylated analogue 12 of 2 exhibits a weak AMPA antagonist activity. |
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