Cell kinetic studies of endothelial cells in the adenocarcinoma EO 771 and the effect of cyclophosphamide |
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Authors: | I D Bassukas G Vester B Maurer-Schultze |
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Institution: | 1. Institut für Medizinische Strahlenkunde der Universit?t Würzburg, Versbacher Strasse 5, D-8700, Würzburg, Federal Republic of Germany
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Abstract: | Cell kinetic studies of endothelial cells in the adenocarcinoma EO 771 growing in C57bl/6j mice and after transplantation
into Balb/c-nu/nu mice, as well as of the effect of cyclophosphamide treatment have been carried out. The3H-thymidine labelling index of endothelial cells decreases from about 8% 3–6 days after tumour inoculation to about 3% at
18 days. This decrease parallels that of the labelling index of tumour cells, i.e. there is a positive correlation between
the labelling index of endothelial cells and that of tumour cells. The labelling index of endothelial cells in the tumour
periphery is two to three times as high as that in the tumour centre reflecting corresponding differences in the rate of proliferation.
There is no difference in the proliferation of endothelial cells whether the tumour grows in C57bl/6j or in Balb/c-nu/nu mice.
After treatment with cyclophosphamide the labelling index of endothelial cells decreases within 2 days to 1–2% and remains
that low despite regrowth of the tumour with increased tumour cell proliferation, indicating that tumour relapse does not
depend on tumour angiogenesis. |
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Keywords: | Endothelial cell proliferation Solid tumour |
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