Zinc tetraruthenated porphyrin binding and photoinduced oxidation of calf-thymus DNA |
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| Authors: | Araki K Silva C A Toma H E Catalani L H Medeiros M H Di Mascio P |
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| Institution: | Instituto de Química, Universidade de S?o Paulo, SP, Brazil. koiaraki@iq.usp.br |
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| Abstract: | The photooxidation of calf-thymus DNA has been investigated in the presence of a supramolecular tetraruthenated zincporphyrin (ZnTRP) sensitizer. A strong interaction of ZnTRP with DNA has been observed, exhibiting a gradual transition from a non-specific electrostatic binding mode to a more specific one at high DNA concentrations. Formation of O2(1delta(g)) has been detected from its near-infrared emission, after the excitation of ZnTRP in dioxygen-containing solutions. In the presence of DNA and dioxygen, ZnTRP promotes efficient photocatalytic oxidation of the 2'-deoxyguanosine sites, via their direct reaction with O2(1delta(g)), as in a previous work on the ZnTRP-photoinduced oxidation of the free nucleosides. |
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