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Synthesis,characterization and tyrosinase inhibitory properties of benzimidazole derivatives |
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| Authors: | Mert Olgun Karatas Bulent Alici Engin Çetinkaya Çi?dem Bilen Nahit Gençer Oktay Arslan |
| Institution: | 1. Faculty of Arts and Sciences, Department of Chemistry, Inonu University, Malatya, 44280, Turkey 2. Faculty of Science, Department of Chemistry, Ege University, Izmir, 35100, Turkey 3. Department of Chemistry, Faculty of Art and Sciences, Balikesir University, Balikesir, 10145, Turkey |
| Abstract: | 1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, 1H NMR, 13C NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzod]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM). |
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