Effect of anticancer drugs on the release of interleukin-6 in vitro |
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Authors: | S I Hasan Barbara A D Blaney J L Turk |
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Affiliation: | (1) The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN London, UK |
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Abstract: | Summary This study investigates the effects of anticancer drugs and immunomodulating agents on the release of interleukin-6 (IL-6) from lipopolysaccharide-stimulated human peripheral blood mononuclear leucocytes in vitro. The addition of non-cytotoxic concentrations of Adriamycin (doxorubicin), vincristine and 4-OOH-cyclophosphamide (the in vitro active analogue of cyclophosphamide) resulted in suppression of IL-6 release. The drugs bleomycin, FK156 d-lactoyl-l-alanyl--d-glutamyl-(l)-meso-diaminopimelyl-(l)-glycine], FK565 heptanoyl--d-glutamyl-(l)-meso-diaminopimelyl-(d)-alanine] and the immunosuppressive agent cyclosporin A did not alter the release of IL-6 in the same experimental system. |
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Keywords: | IL-6 Immunomodulation Drug inhibition |
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