| 胰岛素样生长因子1的结构与功能研究进展 |
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| 引用本文： | 刘宝英,王会信. 胰岛素样生长因子1的结构与功能研究进展[J]. 生物化学与生物物理进展, 1998, 25(4): 311-315 |
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| 作者姓名： | 刘宝英 王会信 |
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| 作者单位： | 北京基础医学研究所，北京 100850;北京基础医学研究所，北京 100850 |
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| 摘 要： | 胰岛素样生长因子1(IGF1)是一种多功能细胞调控因子.它的结构特征为其促生长和物质代谢功能提供依据.集中介绍了IGF1的三维结构、IGF1与相关受体和结合蛋白的结合区以及二硫键在蛋白质折叠中的重要作用.
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| 关 键 词： | 胰岛素样生长因子1，结构 功能，受体，结合蛋白 |
| 收稿时间： | 1997-05-08 |
| 修稿时间： | 1997-07-17 |
Progress in the Studies of Structure and Function of Insulin-like Growth Factor 1 |
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| LIU Bao-ying and WANG Hui-xin. Progress in the Studies of Structure and Function of Insulin-like Growth Factor 1[J]. Progress In Biochemistry and Biophysics, 1998, 25(4): 311-315 |
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| Authors: | LIU Bao-ying and WANG Hui-xin |
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| Abstract: | Insulin-like growth factor 1 is a multifunctional cell regulating factor. It has been demonstrated that structural characteristics of IGF1 provide clues for its growth promoting and anabolic effect. It is concentrated on the three dimensional structure of human IGF1, and the combining regions between IGF1 and relative receptors and binding proteins. It also shows the important role of disulfide bonds in the protein folding. |
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