| 邻啡罗啉-Cu对DNA的损伤及其化学核酸酶活性 |
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| 引用本文： | 马文建,曹恩华.邻啡罗啉-Cu对DNA的损伤及其化学核酸酶活性[J].生物化学与生物物理进展,1998,25(5):407-413. |
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| 作者姓名： | 马文建 曹恩华 |
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| 作者单位： | 中国科学院生物物理研究所，北京 100101;中国科学院生物物理研究所，北京 100101 |
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| 基金项目： | 国家自然科学基金委重点项目(3933008). |
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| 摘 要： | 邻啡罗啉-Cu是一种具有核酸酶活性的配合物，可产生多种形式的DNA损伤，包括碱基修饰、异常碱基位点、链断裂及交联等.近年来，邻啡罗啉-Cu因其切割核酸的性质及作为一种可产生活性氧的模型，引起了学者们浓厚的兴趣，在自由基生物学与医学及核酸化学领域受到广泛的关注.
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| 关 键 词： | 邻啡罗啉-Cu，化学核酸酶 DNA损伤，活性氧 |
| 收稿时间： | 5/3/1997 12:00:00 AM |
| 修稿时间： | 1997/9/19 0:00:00 |
Phenanthroline-Cu Complex Induced DNA Damage and Its Study as a Chemical Nuclease |
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| MA Wen-jian and CAO En-hua.Phenanthroline-Cu Complex Induced DNA Damage and Its Study as a Chemical Nuclease[J].Progress In Biochemistry and Biophysics,1998,25(5):407-413. |
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| Authors: | MA Wen-jian and CAO En-hua |
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| Institution: | Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | Phenanthroline-Cu is a complex that have nuclease activity, it can induce several kinds of DNA damage, including base modifications, abasic sites, strand breaks and DNA protein crosslinks. There is a considerable interest on this complex in recent years in the area of free radical biology and medicine as well as nucleic acids chemistry, for the role of phenanthroline-Cu as a model of generating reactive oxygen species and as a chemical nuclease. |
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| Keywords: | phenanthroline-Cu chemical nuclease DNA damage reactive oxygen species |
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