| 蛋白酶体结构和功能研究进展 |
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| 引用本文： | 彭睿,秦浚川,宋晓龄. 蛋白酶体结构和功能研究进展[J]. 生物化学与生物物理进展, 1998, 25(3): 235-238 |
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| 作者姓名： | 彭睿 秦浚川 宋晓龄 |
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| 作者单位： | 南京大学生物化学系，医药生物技术国家重点实验室，南京 210093;南京大学生物化学系，医药生物技术国家重点实验室，南京 210093;美国Texas大学西南医学中心 |
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| 摘 要： | 蛋白酶体是真核细胞内依赖ATP的蛋白质水解途径的重要成分，负责大多数细胞内蛋白质的降解. 20 S蛋白酶体有多种肽酶活性，其活性位点为Thr. 19 S复合物与20 S蛋白酶体结合成为26 S复合物，能降解泛素化蛋白.近几年来，蛋白酶体的分子组成、亚基、生化机理、胞内功能等方面的研究取得了明显进展.
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| 关 键 词： | 蛋白酶体，结构，功能，蛋白酶体活化因子 |
| 收稿时间： | 1997-03-12 |
| 修稿时间： | 1997-09-16 |
Recent Advances in the Structure and Functions of the Proteasome |
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| PENG Rui,QIN Jun-chuan and SONG Xiao-ling. Recent Advances in the Structure and Functions of the Proteasome[J]. Progress In Biochemistry and Biophysics, 1998, 25(3): 235-238 |
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| Authors: | PENG Rui QIN Jun-chuan SONG Xiao-ling |
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| Affiliation: | Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China;Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China;The University of Texas,Southwestern Medical Center,USA |
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| Abstract: | The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins. The 20 S proteasome whose active site is a threonine,contains multiple peptidase activities. PA700 cappes the 20 S proteasome to form the 26 S complex, by which ubiquitinated proteins are degraded. Advances have been achieved recently in the research about the molecular organization of the 20 S and 26 S particles,their subunits,their intracellular functions and biochemical mechanisms. |
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| Keywords: | proteasome structure function activators of proteasome |
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