白细胞与内皮细胞的粘附

白细胞与内皮细胞相互作用由粘附分子介导.整合素、免疫球蛋白及选择素家族的粘附分子在这两种细胞的粘附中起关键作用.粘附的起始阶段由选择素介导，随后由CD11/CD18复合物与ICAM-1形成更为紧密的结合.多种细胞因子及炎症反应可诱导粘附.抗粘附分子单抗、药物等可抑制粘附.

Leukocyte-endothelial Cell Adhesion

The interaction between leukocytes and endothelial cells is mediated by cell adhesion molecules. There are three families of adhesion molecules which play important roles in cell adhesion. They are integrin family, immunoglobulin superfamily and selectin family. The initial stage of adhesion is mediated by selectins and the firm adhesion is formed thereafter by the binding of CD11/CD18 complex with ICAM-1. Certain cytokines and inflammatory factors can induce cell adhesion mentioned above. The interactions among different adhesion molecules are very complicated. Antibodies directed at adhesion molecules, soluable adhesion molecules, oligopeptides with high affinity for the binding sides of the adhesion molecules, and some drugs can block the adhesion.