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The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia |
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| Authors: | H. G. Miltenburger H. Träger I. -D. Adler A. Schmaltz R. Rathenberg H. Schwegler I. H. Pawlowitzki Ch. Nautsch D. Müller |
| Affiliation: | (1) Institut für Zoologie, Technische Hochschule Darmstadt, D-6100 Darmstadt, Federal Republic of Germany;(2) Institut für Biologie, Abteilung für Genetik, Gesellschaft für Strahlen- und Umweltforschung, D-8032 Neuherberg bei München, Federal Republic of Germany;(3) Institut für Anthropologie und Humangenetik, Universität Heidelberg, D-6900 Heidelberg, Federal Republic of Germany;(4) Institut für Humangenetik, Universität Münster, D-4400 Münster, Federal Republic of Germany;(5) Biological Research Laboratories of the Pharmaceuticals Division of Ciba-Geigy Limited, Basle, Switzerland |
| Abstract: | Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3 x 125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3--16 mg/kg). |
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