Ultrastructural analysis of the effects of erythromycin on the morphology and developmental cycle of Chlamydia trachomatis HAR-13 |
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Authors: | Richard B Clark Peter F Schatzki Harry P Dalton |
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Institution: | (1) Department of Microbiology, Medical College of Virginia, Richmond, Virginia, USA;(2) Department of Pathology, McGuire Veterans Administration Hospital, Richmond, Virginia, USA;(3) Department of Pathology, Medical College of Virginia, Richmond, Virginia, USA;(4) Present address: Dept. of Microbiology, The Mount Sinai Hospital, 10029 New York, USA |
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Abstract: | The effect of erythromycin (10 g/ml) on the morphology and developmental cycle of Chlamydia trachomatis HAR-13 was examined by electron microscopy. When the antibiotic was added later than 24 h post infection, the HAR-13 morphology or developmental cycle was not altered. Addition at 18 or 24 h post infection inhibited glycogen production, blocked the transformation of the reticulate body to elementary body, and produced ghost bodies and reticulate bodies twice the diameter of untreated reticulate bodies. When erythromycin was added within 12 h post infection, the conversion of the elementary body to reticulate body was inhibited. Erythromycin (10 g/ml) was bactericidal to strain HAR-13 throughout the developmental cycle.Abbreviations CXM
cycloheximide media
- IFU
inclusion forming units
- MEM
minimal essential medium |
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Keywords: | Chlamydia trachomatis Erythromycin Developmental cycle Elementary body Reticulate body |
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