Spontaneous lipid bilayer transmembrane electrical oscillations induced by concanavalin A-polysaccharide interaction |
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| Authors: | U J Krull M Thompson |
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| Affiliation: | 1. Department of Chemical Sciences, University of Johannesburg, Doorfontein, Johannesburg, South Africa;2. Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria, South Africa;3. Department of Polymer Science and Technology, University of Calcutta, Kolkata, West Bengal, India;4. Department of Pharmacology, Coochbehar Government Medical College & Hospital, Coochbehar, West Bengal, India;1. Key Laboratory of Rare Earth, Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341000, China;2. School of Rare Earths, University of Science and Technology of China, Hefei 230026, China;3. Key Laboratory of Green Process and Engineering, National Engineering Research Center of Green Recycling for Strategic Metal Resources, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China |
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| Abstract: | Potassium ion currents through bilayer lipid membranes were modified by the membrane-surface reaction of concanavalin A and the polysaccharides dextran and glycogen. Aggregative reaction with glycogen occasionally induced spontaneous periodic ion current fluctuations with cycle times of minutes and durations of over one hour. Different electrochemical characteristics were observed between large planar lipid membranes and filter paper supported membranes, providing an indication that the aqueous unstirred surface layer participates in the control of the surface aggregative event. Lipid chemical composition was implicated in the development of spontaneous oscillations. |
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