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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives |
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| Authors: | Krueger A Chris Madigan Darold L Green Brian E Hutchinson Douglas K Jiang Wen W Kati Warren M Liu Yaya Maring Clarence J Masse Sherie V McDaniel Keith F Middleton Tim R Mo Hongmei Molla Akhteruzzaman Montgomery Debra A Ng Teresa I Kempf Dale J |
| Institution: | Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com |
| Abstract: | Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs. |
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