The expression of receptivity markers in the fallopian tube epithelium |
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Authors: | A Makrigiannakis M Karamouti G Petsas N Makris G Nikas A Antsaklis |
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Institution: | (1) In Vitro Fertilization Unit, Department of Obstetrics and Gynaecology, Medical School, University of Crete, Heraklion, 71003, Greece;(2) “Alexandra” Maternity Hospital, Athens University Medical School, Athens, Greece;(3) “Athens Innovative Microscopy”, Skra 36 Voula, 16673 Athens, Greece;(4) Department of Obstetrics/Gynaecology, Medical School, University of Crete, 71003 Heraklion, Greece |
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Abstract: | Pinopodes represent the morphological and integrins, the biomollecular markers of endometrial receptivity. We studied using
scanning electron microscopy, the expression of pinopodes on tubal samples and their corresponding endometria, from 21 women
of reproductive age (7 from proliferative phase, 7 from day LH +5 and 7 from day LH +7). In addition, we examined the immunohistochemical
staining of integrins αvβ3, αvβ5 and their ligands, fibronectin (FN) and osteopontin (OPN) in the same tubal epithelium samples.
Pinopodes were detected on the tubal epithelium exclusively during day LH +7, coincident with their formation in the endometrium
and synchronous to αvβ3 sharp increase in the oviduct epithelium, suggesting a regulation similar to the endometrium. In contrast,
αvβ5, FN and OPN remained unchanged during the cycle. These results show for the first time the formation of pinopodes in
the tubal epithelium at the time of endometrial receptivity and correlate it with the upregulation of the intact dimmer αvβ3
in the tubes. |
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Keywords: | Pinopodes Integrins Implantation Tubal epithelium Receptivity |
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