Selenazolidines as novel organoselenium delivery agents. |
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| Authors: | Y Xie M D Short P B Cassidy J C Roberts |
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| Affiliation: | Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA. |
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| Abstract: | Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention. |
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