A lipophilic adjuvant carrier system for antigenic peptides |
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| Authors: | Anikó Horvá th, Colleen Olive, Allan Wong, Timothy Clair, Penny Yarwood, Michael Good Istvan Toth |
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| Affiliation: | (1) School of Pharmacy, The University of Queensland, Brisbane, Australia;(2) Joint Research Organization of the Hungarian Academy of Sciences, Semmelweis University Budapest, Budapest, Hungary;(3) Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane QLD, Australia |
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| Abstract: | A lipoamino acid based synthetic peptide, (Lipid Core Peptide, LCP) derived from the conserved region of group A streptococci (GAS) was evaluated as potential candidate in a vaccine to prevent GAS-associated diseases, including rheumatic heart disease and post-streptococcal acute glomerulonephritis. Multiple copies of a peptide sequence from the bacterial surface M protein were incorporated into a lipid core and it was used to immunize mice with and without the application of adjuvant. The LCP construct had significantly enhanced immunogenicity compared with the monomeric peptide epitope. Furthermore, the peptides incorporated into the LCP system generated antibodies without the use of any conventional adjuvant. |
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| Keywords: | group A streptococci lipid core peptides (LCP) lipoamino acid multiple antigenic peptides peptide delivery solid-phase peptide synthesis vaccination |
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