Biosynthetic systems for nonribosomal peptide antibiotic assembly |
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Authors: | Henning D Mootz Mohamed A Marahiel |
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Institution: | Philipps-Universität Marburg, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse, 35032 Marburg, Germany |
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Abstract: | Modular peptide synthetases, which act as the protein templates for the synthesis of a large number of peptide antibiotics and siderophores, hold great potential for the development of novel compounds. Recently, significant progress has been made towards understanding their molecular architecture and substrate specificity. The first crystal structure of a peptide synthetase has been solved, and the enzymes responsible for post-translational modification of peptide synthetases have recently been discovered. These will allow addressing important yet poorly understood mechanistic aspects. |
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Keywords: | Abbreviations: aa amino acid ACP acyl carrier protein ACPS acyl carrier protein synthase CoASH coenzyme A PCP peptidyl carrier protein P-pant 4′-phosphopantetheine |
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