Regeneration of skeletal muscle |
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Authors: | Turner Neill J Badylak Stephen F |
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Institution: | (1) McGowan Institute for Regenerative Medicine, University of Pittsburgh, Bridgeside Point 2, 450 Technology Drive, Pittsburgh, PA 15219, USA;(2) Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA; |
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Abstract: | Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options
for volumetric muscle loss are available. Autologous muscle grafts or muscle transposition represent possible salvage procedures
for the restoration of mass and function but these approaches have limited success and are plagued by associated donor site
morbidity. Cell-based therapies are in their infancy and, to date, have largely focused on hereditary disorders such as Duchenne
muscular dystrophy. An unequivocal need exists for regenerative medicine strategies that can enhance or induce de novo formation
of functional skeletal muscle as a treatment for congenital absence or traumatic loss of tissue. In this review, the three
stages of skeletal muscle regeneration and the potential pitfalls in the development of regenerative medicine strategies for
the restoration of functional skeletal muscle in situ are discussed. |
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