Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons |
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| Authors: | Hille B Beech D J Bernheim L Mathie A Shapiro M S Wollmuth L P |
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| Institution: | Department of Physiology and Biophysics, University of Washington, Seattle 98195, USA. |
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| Abstract: | Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists. |
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