The effect of frontal cortex lesion on the activity of the dopaminergic system in rat striatum |
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| Authors: | M Sieklucka-Dziuba A Wamil Z Kleinrok |
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| Institution: | Department of Pharmacology, School of Medicine, Lublin. |
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| Abstract: | The experiment was carried out on male Wistar rats weighing 180-220 g with lesion in the cortex of the frontal lobe. The activity of the dopaminergic system was studied by means of behavioural tests such as determination of spontaneous motor activity, apomorphine-induced stereotypy, haloperidol-induced catalepsy. Increased intensity of stereotypy was observed reaching a maximum 14 days after frontal lobe damage. Moreover, a slight tendency was observed for inhibition of haloperidol-induced catalepsy without changes in the spontaneous motor activity of the animals. Biochemical investigations demonstrated reduced dopamine content in the striatum on the side of the lesion. |
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