Missing genes in metabolic pathways: a comparative genomics approach |
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| Authors: | Osterman Andrei Overbeek Ross |
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| Affiliation: | Integrated Genomics, Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. andrei@integreatedgenomics.com |
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| Abstract: | The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery. |
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