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Synthesis and inotropic activity of hydroindene derivatives |
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| Authors: | Sevillano L G Melero C P Boya M López J L Tomé F Caballero E Carrón R Montero M J Medarde M Feliciano A S |
| Institution: | a Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus ‘Miguel de Unamuno’, 37007, Salamanca, Spain b Laboratorio de Farmacología, Facultad de Farmacia, Universidad de Salamanca, Campus ‘Miguel de Unamuno’, 37007, Salamanca, Spain |
| Abstract: | A synthetic approach to hydroindenic inotropic agents has been developed, starting from enantiopure Hajos-Parrish (1). Hajos-Wiechert (2), and related diketones. Their transformation into C-1 formyl derivatives and other subsequent synthetic targets is described. The results of the thermodynamic equilibration between both epimers of each formyl derivative are analysed. The inotropic activities of selected compounds on right and left atrial preparations are also evaluated and discussed. |
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