Preparation of S-(N6,N6-dimethyladenosyl)-L-methionine |
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Authors: | K Ramalingam R W Woodard |
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Affiliation: | Byelorussian Research Institute of Epidemiology and Microbiology, Minsk U.S.S.R. |
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Abstract: | 4′,5′-Unsaturated nucleosides are obtained by the action of 1,5-diazabicyclo-[5.4.0]undec-5-ene on N1- and N3-(methyl 2,3,4-tri-O-acetyl-β-d-glucopyranosyluronate)-5-fluorouracil. The 2H1 conformation of N1- and N3-(methyl 4-deoxy-α-l-threo-hex-4-enopyranosyluronate)-5-fluorouracil has been established by 1H-n.m.r. and c.d. methods. Interaction of the heterocyclic base and the double bond of the sugar moiety is demonstrated. |
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