Dynamical synaptic plasticity: a model and connection to some experiments |
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Authors: | A Whitehead M I Rabinovich R Huerta V P Zhigulin Henry D I Abarbanel |
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Institution: | (1) Institute for Nonlinear Science, University of California, San Diego, CA 92093-0402, USA, US;(2) GNB, E.T.S. de Ingenería Informática, Universidad Autónoma de Madrid, 28049 Madrid, Spain, ES;(3) Department of Physics, MC 103-33, California Institute of Technology, Pasadena, CA 91125, USA, US;(4) Institute for Nonlinear Science, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego, La Jolla, CA 93093-0402, USA, US |
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Abstract: | Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments
of Wu et al. (2001) J Physiol 533:745–755]. We show that the model is quantitatively consistent with their experimental protocols
producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict
the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.
Received: 3 September 2002 / Accepted in revised form: 22 October 2002 / Published online: 24 February 2003
Correspondence to: H.D.I. Abarbanel (e-mail: hdia@jacobi.ucsd.edu)
Acknowledgements. We are very grateful to A. Selverston and D. Feldman for conversations about this work. This work was partially supported
by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Engineering and Geosciences, under grants No.
DE-FG03-90ER14138 and No. DE-FG03-96ER14592, by a grant from the National Science Foundation, NSF PHY0097134, by a grant from
the Army Research Office, DAAD19-01-1-0026, by a grant from the Office of Naval Research, N00014-00-1-0181, and by a grant
from the National Institutes of Health, NIH R01 NS40110-01A2. This work was also partially supported by M. Ciencia y Tecnologa
BFI2000-0157 (R.H.). |
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