Simple and rapid procedure for synthesis of deoxynucleoside 3'-2-cyanoethyl-N,N-diisopropyl-amino phosphites |
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Authors: | A Kraszewski K E Norris |
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Affiliation: | Polish Academy of Sciences, Institute of Bio-organic Chemistry, Poznań. |
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Abstract: | 2-Cyanoethyl-bis/N,N-diisopropyl/phosphoamidite can be prepared from PCl3 by a very fast and efficient procedure. Without purification it was used for the phosphitilation of suitably protected deoxynucleosides which after simple purification are obtained with a high yield, in a stable and easy to manage form. |
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