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ALDH2 polymorphism for the risk of cervical carcinogenesis |
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| Authors: | Osamu Nunobiki Daisuke Sano Kyoko Akashi Taro Higashida Toshitada Ogasawara Hikari Akise Shinji Izuma Kiyo Torii Yoshiaki Okamoto Ichiro Tanaka Masatsugu Ueda |
| Institution: | 1.Department of Medical Technology,Kobe Tokiwa University,Kobe,Japan;2.Department of Obstetrics and Gynecology,Kyoto Prefectural University,Kyoto,Japan;3.Department of Obstetrics and Gynecology,Akou City Hospital,Akou,Japan;4.Department of Obstetrics and Gynecology,Okubo Hospital,Okubo,Japan;5.Cytopathology and Gynecology,Osaka Center for Cancer and Cardiovascular Disease Prevention,Osaka,Japan |
| Abstract: | To investigate the clinical significance of ALDH2 genetic polymorphisms in cervical carcinogenesis. ALDH2 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 195 cervical smear in exfoliated cervical cell samples using Real-Time polymerase chain reaction (PCR) System. The frequency for the AG+AA genotype was seven in the normal group (70.0 %), 16 in the LSIL group (57.1 %), and 27 in the HSIL group (90.0 %). A significant difference was found between the LSIL and HSIL groups (P = 0.0064). Patients with HSIL lesions frequently had high-risk HPV infections and concurrently belonged to the AG+AA group. ALDH2 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population. |
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