Sialic acid-binding lectins in the “whip scorpion” (Mastigoproctus giganteus) serum |
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Authors: | Gerardo Raul Vasta Elias Cohen |
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Institution: | Department of Biochemistry, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, USA;Department of Laboratory Medicine, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York 14263, USA |
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Abstract: | Sialic acid-specific lectins have been detected in the serum of the “whip scorpion,” Mastigoproctus giganteus. When compared to Limulus lectins, Mastigoproctus agglutination profiles for a panel of untreated and enzyme-treated vertebrate erythrocytes were almost identical except for the agglutination of nonhuman primate erythrocytes. However, both chelicerate species exhibited heterogeneous serum lectins which showed some differences in their serological reactivity. At least three distinct specific fractions could be demonstrated in Mastigoproctus serum by crossed absorption and hemagglutination-inhibition experiments. These fractions are specific for sialic acids and/or sialoconjugates but also bind substances such as N-acetylglutamic acid, N-acetylmuramic acid, chitobiose, and chitotriose. These adjunct specificities are important clues in the interpretation of the possible biological role of chelicerate lectins. |
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Keywords: | Lectin hemagglutinin sialic acids carbohydrate specificity |
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