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Propagated Perturbations from a Peripheral Mutation Show Interactions Supporting WW Domain Thermostability
Authors:Meiling Zhang  David A Case  Jeffrey W Peng
Institution:1. Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA;2. Department of Chemistry and Chemical Biology, Rutgers University, 174 Frelinghuysen Road, Piscataway, NJ 08854, USA
Abstract:
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  • Keywords:mutational landscape  thermostability  β-sheet folding  allostery  relaxation dispersion  interaction network  WW domain  Pin1  NMR  MD
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