Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells |
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Authors: | Laurens W. J. Bosman Jana Hartmann Jaroslaw J. Barski Alexandra Lepier Michael Noll-Hussong Louis F. Reichardt Arthur Konnerth |
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Affiliation: | 1. Institut für Neurowissenschaften, Technische Universit?t München, Biedersteiner Strasse 29, 80802, München, Germany 2. Institut für Physiologie, Ludwig-Maximilians-Universit?t, München, Germany 3. Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, USA
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Abstract: | The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast to other types of neurons, Purkinje cells do not need TrkB for dendritic growth and spine formation. Instead, we find a moderate delay in the maturation of GABAergic synapses and, more importantly, an abnormal multiple climbing fiber innervation in Purkinje cells in trkB-deficient mice. Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain. Electronic Supplementary Materials Supplementary Materials is available in the online version of this article at |
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