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Aryl urea analogs with broad-spectrum antibacterial activity |
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| Authors: | Seth Punit P Ranken Ray Robinson Dale E Osgood Stephen A Risen Lisa M Rodgers Elizabeth L Migawa Michael T Jefferson Elizabeth A Swayze Eric E |
| Institution: | Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, CA 92008, USA. pseth@isisph.com |
| Abstract: | The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia. |
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