Digestion and absorption of trioleoyl-thioglycerol in the rat |
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Authors: | B. Åkesson S. Gronowitz P. Michelsen |
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Affiliation: | Department of Physiological Chemistry and Division of Organic Chemistry, Chemical Center, University of Lund, P.O. Box 750, S-220 07 Lund 7 Sweden |
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Abstract: | A triacylglycerol analogue, rac-1,2-di-O-oleoyl-3-S-oleoyl-3-thioglycerol, was fed to rats and chyle acylglycerols were analyzed. Triacylglycerol was the dominating chyle lipid but X-triacyl-1-thioglycerol constituted approx. 6% of total chyle lipids. Its identity was verified by ultraviolet and mass spectra and its stereochemical structure by ORD and CD. The proportions of triacyl-1-thio-sn-glycerol/triacyl-3-thio-sn-glycerol were and in two experiments. Possible reasons for this stereospecificity are discussed. The study shows that the stereochemical configuration of lipids isolated from biological material can be assessed by ORD and CD. |
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