Synthesis of specifically deuterated saturated and unsaturated phosphatidylserines |
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Authors: | Jeffery Browning Joachim Seelig |
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Institution: | Department of Biophysical Chemistry, Biocentre of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel Switzerland |
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Abstract: | A facile chemical synthesis of 1,2-dioleoyl and 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine as well as the synthesis of several deuterated derivatives of phosphatidylserine (2 and 3 positions of serine and in the 3-glycerol position) are described. 360 MHz 1H NMR spectra of phosphatidylserine and the optical activity of various phosphatidylserine diastereomers were measured. |
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